PHA (Gluconolactone)Benefits, how to use & safety
Exfoliation for skin that can't handle exfoliation.
What is PHA (Gluconolactone)?
Polyhydroxy acids such as gluconolactone and lactobionic acid are the new generation of gentle exfoliants. Their large molecules stay near the surface, so they exfoliate gradually while also hydrating and offering antioxidant benefits.
How it works
PHAs loosen dead surface cells like AHAs but penetrate slowly, which limits stinging. They also bind water and support the barrier, making them suitable alongside retinoids or after procedures with medical advice.
Key benefits
- Gentle exfoliation with minimal stinging
- Improves hydration
- Antioxidant protection
- Suitable for sensitive and rosacea-prone skin
- Sensitivity
- Dullness
- Dehydration
Best suited for: Sensitive, dry, rosacea-prone and eczema-prone skin, as well as beginners to exfoliation.
How to use it
Use 3–10% PHA two to three times weekly, or daily if tolerated, in the evening. Follow with moisturiser and sunscreen by day.
Pairs well & what to avoid
- Hyaluronic acid
- Niacinamide
- Retinol
- Layering with multiple strong acids
- Expecting rapid results
Safety & side effects
Very well tolerated. Mild tingling can occur. As with all exfoliants, use sun protection.
Frequently asked
Is PHA as effective as AHA?
It is gentler and slower, so the effect is subtler, but consistent use still improves glow and texture.
Can PHA be used with retinol?
Yes, often better than stronger acids, but alternate nights if skin feels sensitive.
Is PHA good for rosacea?
It is one of the more tolerable exfoliants for reactive skin, but check with your dermatologist.
Educational content only, not medical advice. Individual skin responds differently. Patch-test new actives, introduce one at a time, and consult a dermatologist for persistent skin concerns, pregnancy or breastfeeding questions, or any prescription treatment.
